Shua

New article (1) led by our collaborators in Paris, that makes heavy use of my older work MEMPROT (2) for the low-resolution determination of protein/detergent complex structure in solution from scattering data. Overall the paper represents an example of how good quality size-exclusion chromatography small-angle scattering data together with approriate modelling may elucidate the structure of membrane proteins solubilized by detergents.

(1) Unraveling ShuA detergent-induced colloidal behavior in solution: A comprehensive SEC-MALS, SAXS, and SANS study A. Pozza, A. Martel, M. Moir, T. A. Darwish, K. Wimalan, A. Koutsioubas, S. Combet, F. Bonneté Protein Science (2025)

(2) Memprot: a program to model the detergent corona around a membrane protein based on SEC-SAXS data J. Pérez and A. Koutsioubas Acta Cryst. (2015). D71, 86-93